Sambucus nigra Lectin (SNA/EBL II) - Pure

Sambucus nigra Lectin (SNA/EBL II) - Pure

$130.00 Sale
SKU# 21511157-1

Product Description

Sambucus nigra lectin (EBL II/SNA II) isaffinity purified from elderberry bark. This lectin is a glycoprotein containing 7.8% carbohydrate and is not blood group specific. It is composed of two subunits and has a molecular weight of 140,000. EBL II has a specificity for carbohydrates containing terminal N-acetylgalactosamine and galactose residues.
The blood group A-active trisaccharide containing L-fucosyl group linked ?1-2 to galactose is 10-fold lesser as an inhibitor than the parent oligosaccharide (GalNAc ?1-3Gal), which suggests steric hindrance to binding by the ?-L-fucosyl group and explains the failure of the lectin to exhibit blood group A specificity.
EBL II induces caspase-dependent apoptosis at low concentrations (nM) order, leading to typical symptoms of cell death in sensitive cells. This effect seems dependent on the carbohydrate binding B-chain.

Technical Specifications

Molecular Weight: 140 kDa
Synonyms: SNA/EBL II
Shelf Life: 2 years
Storage Temperature: -20°C
Hazardous Shipping: Non-hazardous