Ulex europaeus Lectin (UEA II) - Pure
Regular price
$155.81
Sale
SKU# 21560049-1
Product Description
Ulex europaeus agglutinin (UEA II) is isolated from gorse seeds and separated from crude extract. This lectin is a glycoprotein that consists of four 24,000 Da monomer subunits that require Ca2+ for binding to its ligands through carbohydrate recognition domain. It is specific for di-N-acetylchitobiose, an oligomer of GlcNAc. The monosaccharide GlcNAc is not an inhibitor of the lectin activity. UEA II has no mitogenic activity and agglutinates type O erythrocytes with greater interest than type A3 erythrocytes. Treatment of the lectin with EDTA abolishes agglutinating activity, although activity returns with the addition of calcium.
UEA II is a potent inhibitor of the lectin complement pathway following endothelial oxidative stress. The molecular mechanism of UEA II-induced inhibition of the lectin complement pathway appears to be through competition for a common binding site on the endothelial cell and not at the level of mannose-binding lectin (MBL) inhibition.
This product comes in a lyophilized form and is stored at -20ºC. Calcium, manganese, and zinc ions are required for binding.
Technical Specifications
| Molecular Weight | : | 96 kDa |
| Synonyms | : | UEA II |
| Appearance Form | : | White to off-white |
| Shelf Life | : | 2 years |
| Storage Temperature | : | -20°C |
| Hazardous Shipping | : | Non-hazardous |